Hi @okl
yes that is possible, I would recommend to try this way.

Step 1: select trigger when email arrives
Step 2: use initialize variable action to store the list of email subject you want to exclude from detection in array

Step 3: same as step2, create another array which stores the list of email addresses which you want to exclude from detection

Step 4: use conditio to check whether the email subject of triggered mail is present in array of excluded subjects or email addresses of triggered mail is present in array of excluded email ids like below

If the condition is True, it means subject or email id of your current email need to excluded from detection, else it should go for detection
Hope it helps !
Mark it as solution if it resolves your query !