We need to check to see if a JSON value is null or not. Here is the JSON:
"customfield_25300": null,
When using the "If" statement, with "Isn't empty", a "variable doesn't have a property" error message is presented (screenshots below). This error message doesn't appear, however, if customfield_25300 contains a value (e.g. "John") instead of null. This makes us think that our value in "First operand" is correct, but that the null in the JSON is in some way confusing the "If" statement.
How do you check for null in Power Automate Desktop?

