Sure,
So it looks like you are already setting this as a variable, varReturnResponse, so you should set the flow run as varReturnResponse then use an if condition separately afterwards
Something like this (replaced your control names with generics, please change all of those to your control names):
Set(varReturnResponse,
FlowName.Run(
abc.Value,
def.Selected.Value,
ghi.Selected.Displayname,
jkl.Value,
If(IsBlank(mno.Value), "", mno.Value),
If(IsBlank(pqr.Value), "", pqr.Value),
If(IsBlank(stu.Selected.Value), "", stu.Selected.Value),
If(IsBlank(vwx.Selected.Value), "", vwx.Selected.Value),
User().FullName,
User().Email
)
);
If(Len(varReturnResponse.successmsg)>0,
Notify("" & varReturnResponse.successmsg, NotificationType.Success, 10000),
Notify("" & varReturnResponse.errormsg, NotificationType.Error, 10000)
)
Cheers,
Sancho