Hi @galos,
Could you please tell me that what is the column type of the Director and VP, both Text column?
Show me how you set the update property of the data card corresponding to the VP and Director?

What's more, if you populate the Manager ComboBox with the items from Table1, I think this is the key to your issue.
Here is a simple demo for your reference, I populate the ComboBox with another field from another list, here is how I set the Items property and DefaultSelectedItems property of the ComboBox:
1). Items property:
Distinct(Table1,Manager)
2). DefaultSelectedItems property:
[ThisItem.Manager]
3). Set the Items property and the DefaultSelectedItems of the ComboBox corresponding to Director as below:
Filter(Table1,Manager=ComboBox10.Selected.Result).Director
DefaultSelectedItems of the ComboBox corresponding to Director as below:
[ThisItem.Director]