Hi @ erikf,
Could you please share a screenshot of the configuration of your flow?
Do you want the flow would be triggered when the email is sent by a email address with a specific domain?
Microsoft flow support to the flow would be triggered when the email is sent by a specific email address currently,
Triggering a flow when the email is sent by a email address with a specific domain is not supported in microsoft flow currently,
If you would like this feature to be added in Microsoft Flow, please submit an idea to Flow Ideas Forum:
https://powerusers.microsoft.com/t5/Flow-Ideas/idb-p/FlowIdeas
However, you could add a condition under the trigger to check if the email is sent by the specific domain, if the email is sent by the specific domain, you could add some action under the step, if the email isn't sent by the specific domain, do nothing.
I have made a test on my side,you could refer to screenshot below to create the flow:

When an email arrives by a domain "microsoft", the flow would run successfully as below:

Regards,
Alice Zhang