When I am building long Flows with long expressions I find I run into an issue where, when I amend an expression, clicking the Update button doesn;t save the changes. I can see this by immediately hovering over the expression block and the tooltip confirms the changes haven't saved.
This only seems to become an issue when Flows grow to a particular size (not sure what the threshold is though).
This can be very confusing when testing a change and seeing no difference. Now I always double check changes to expressions. The workaround I have found is to make my changes, copy the entire expression, delete all text in the expression and paste it back in. This has a 100% success rate (so far!)
For info, I am using Chrome.