If you want to do UI automation, there is currently no way to have such flows running while using your computer. Only certain actions can be run in the background, such as working with files and folders, Excel, scripting, etc. Some web automation actions also work fine in a browser without interfering with your mouse and keyboard. But actions under the UI automation actions group, as well as the Mouse and keyboard actions group, and any actions involving images will require that you do not use the PC while the flow runs.
If you need to use it, I would suggest getting a virtual machine to run your flows. You can get a hosted machine from Microsoft, or find another cloud infrastructure supplier where you could rent a VM from.
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