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Yes, you can do this using a variable in the Default property of the checkbox you want to make dependent on another. Example, using two checkboxes: Checkbox1 and Checkbox2
In the OnCheck property of Checkbox1, put: UpdateContext({ varIsChecked: true });
In the OnUnCheck property of Checkbox1, put: UpdateContext({ varIsChecked: false });
In the Default property of Checkbox2 (or its parent card), put: varIsChecked
You mentioned you need to keep the Default property referring to ThisItem.xxxx when the form is in Edit mode. You can use conditional logic to accomplish this:
If(myForm.Mode = FormMode.Edit, ThisItem.xxxx, varIsChecked)
Hope that helps,
Bryan