I don't know how many combo/Drop downs you have but you can do this.
When the App Loads
Create an Collection like
ClearCollect(MyDropDownsEditableInfo,
{ DropDown: 1, Editable: true },
{ DropDown: 2, Editable: false},
{ DropDown: 3, Editable: false },
{ DropDown: 4, Editable: false },
{ DropDown: 5, Editable: false }
);
//Then in the Display Mode for each
// You would swap the number (2 or 3,4,5 etc) depending on which Control you were on
If(LookUp(MyDropDownsEditableInfo, DropDown = 2).Editable, DisplayMode.Edit, DisplayMode.Disabled)
//Next what you do is, whereever the code is, that considers DropDown1 Done, you put
Patch(MyDropDownsEditableInfo, LookUp(MyDropDownsEditableInfo, DropDown = 2), { Editable: true});
//And you would do this pattern each time
//And in your reset or when they do new or whatever
UpdateIf(MyDropDownsEditableInfo, Editable = true And DropDown > 1, {Editable: false });