Thank you @Anchov & @RJM07
Using either of those, the reset button removes the entry from the combo box but it does something weird to the gallery view that the combo box filters. Rather than showing all entries when its reset, it shows none.
Weirdly it also doesn't update the Filter(s) applied visual which implies its not really empty??
Any ideas?

Filter applied visual code
If(IsBlank(ComboBox4_AreasSupported) && IsBlank(ComboBox4_Characteristics) && IsBlank(ComboBox4_CliftonStrengths) && IsBlank(txtInput_Search) && IsBlank(txtInput_Search_Name) && IsBlank(ComboBox4_Initiatives) && IsBlank(ComboBox4_Capacity) ,Icon.FilterFlat,Icon.FilterFlatFilled)
Gallery 'Items' code
Sort(
Search(
AddColumns(
Search(
Filter(
'Find a Mentor',
And(
Or(
IsBlank(ComboBox4_Characteristics.SelectedItems),
IsEmpty(ComboBox4_Characteristics.SelectedItems),
!(false in ForAll(
ComboBox4_Characteristics.SelectedItems,
ThisRecord.Value in 'Top 5 mentor characteristics'.Value
))
),
Or(
IsBlank(ComboBox4_AreasSupported.SelectedItems),
IsEmpty(ComboBox4_AreasSupported.SelectedItems),
!(false in ForAll(
ComboBox4_AreasSupported.SelectedItems,
ThisRecord.Value in 'Areas Supported'.Value
))
),
Or(
IsBlank(ComboBox4_CliftonStrengths.SelectedItems),
IsEmpty(ComboBox4_CliftonStrengths.SelectedItems),
!(false in ForAll(
ComboBox4_CliftonStrengths.SelectedItems,
ThisRecord.Value in 'Top 5 Clifton Strengths'.Value
))
),
Or(
IsBlank(ComboBox4_Capacity.SelectedItems),
IsEmpty(ComboBox4_Capacity.SelectedItems),
'Current Capacity?'.Value in ComboBox4_Capacity.SelectedItems.Value
),
Or(
IsBlank(ComboBox4_Initiatives.SelectedItems),
IsEmpty(ComboBox4_Initiatives.SelectedItems),
'Initiatives supported'.Value in ComboBox4_Initiatives.SelectedItems.Value
)
)
),
txtInput_Search.Text,
"AboutyouasaMentor"
),
"MentorName",
'Mentor Name'.DisplayName
),
txtInput_Search_Name.Text,
"MentorName"
),
MentorName
)