I get errors when I try to implement your solution.
In my app I have a dropdown with Items = ["","Study","Holiday","Other"]
I have tried to adjust your solution:
Not(ThisItem.Color in ["Red","Black","Blue"]),
to :
Not(ThisItem.'column name' in ["","Study","Holiday""Other"]),
The error message is "Expected operator."
I have copied your examples and only changed Color to 'column name' and substituted your values by my Item values.
So I do not see a missing operator (comma).
I have tried to add .Text after the column name but that did not solve the error.